Complement-derived leukotactic factors in inflammatory synovial fluids of humans

Complement system in synovial fluids from patients with rheumatoid arthritis.

Immunological processes have been thought to play a role in rheumatoid arthritis, but no conclusive evidence has yet been obtained. Rheumatoid factor (RA factor) is known to be an antibody-like protein frequently found in the sera of patients with rheumatoid arthritis, but it has not been proved that it has any immediate relationship with the inflammatory processes of the disease, and the speci...

T cell derived cytokines in psoriatic arthritis synovial fluids.

OBJECTIVE The aim of this study was to investigate the concentrations of T cell derived cytokines in the synovial fluids (SFs) of patients with psoriatic arthritis (PsA) in comparison with rheumatoid arthritis (RA) and osteoarthritis (OA). METHODS Th1 type cytokines (interleukin 2 (IL2), tumour necrosis factor beta (TNF beta), and interferon gamma (INF gamma) and Th2 type cytokines (IL4, IL10...

Leukotactic Factors Elaborated by Virus-infected Tissues

Infection of chick embryos wih either Newcastle disease virus or mumps virus and infection of BGM cell cultures with mumps virus result in the elaboration of chemotactic activity for neutrophils and macrophages. These factors cannot be found in lysates of uninfected cells. They do not appear to be associated with the viral particles per se, but rather are present in virus-free supernates from i...

Naturally occurring anti-inflammatory factors in the synovial fluids of patients with rheumatic disease and their possible mode of action.

Evidence has been shown that pathological synovial fluid contained a substance capable of stabilizing rat liver lysosomes which was partly inactivated by treatment with trypsin and by storage. Such synovial fluid also appeared to contain a substance which labilized lysosomes and which was more stable than the stabilizing substance. (2) The lysosomal stabilizing substance described above was non...

Hemolytic Complement in Synovial Fluid.